Publicações Científicas
Confira publicações científicas do Dr. Carlos Branco
Rheumatic Fever a neglected and underdiagnosed disease. New perspective on diagnosis
The Rheumatic fever (RF) and the rheumatic heart disease (RHD) remain important health problems among populations of developing countries1. The number of studies is scarce, and public and private investments are practically inexistent. In addition, the cases of rheumatic fever are underdiagnosed, and are recognized only following permanent valve damage through the manifestation of carditis, more frequently represented by mitral stenosis.
Incidental histological diagnosis of acute rheumatic myocarditis case report
Rheumatic fever (RF) remains endemic in many countries and frequently causes heart failure due to severe chronic rheumatic valvular heart disease, which requires surgical treatment. Here, we report on a patient who underwent an elective surgical correction for mitral and aortic valvular heart disease and had a post-operative diagnosis of acute rheumatic carditis. The incidental finding of Aschoff bodies in myocardial biopsies is frequently reported in the nineteenth-century literature, with prevalences as high as 35%, but no clinical or prognostic data on the patients is included.The high frequency of this finding after cardiac surgery in classical reports suggests that these patients were not using secondary prophylaxis for RF. We discuss the clinical diagnosis of acute rheumatic myocarditis in asymptomatic patients and the laboratorial and imaging methods for the diagnosis of acute rheumatic carditis. We also discuss the prognostic implications of this finding and review the related literature.
Early Diagnosis and Treatment in Infective Endocarditis Challenges
Infective endocarditis (IE), a microbial infection of the cardiac or adjacent vascular endothelium, remains a feared disease, although the modern diagnosis systematizations date back to 1885 by Osler.1
Although relatively uncommon, 2 with approximately 3-10 cases per 100,000 individuals/year, 3 the mortality remains high: more than one-third of patients die in the first year after the diagnosis.1,4 Only early diagnosis and treatment, whether exclusively clinical or associated with cardiac surgery, may interfere to reduce this high mortality rate. IE used to be more frequent in young and middle-aged adults with rheumatic or congenital heart disease.3 However, recent studies have shown a significant reduction in the incidence of IE in these groups, especially in more developed countries.
Is population‐based screening for rheumatic heart disease precluded by the Cairo
The recently promulgated 2017 “Cairo Accord on Rheumatic Heart Disease—From Molecules to The Global Community” was a land‐ mark in global cardiology wherein stakeholders from low and mid‐ dle per capita income countries (LMIC) set international priorities for a disease largely affecting their own populations, in lieu of di‐ rectives from high income country experts.1 The Accord addresses the consequences of rheumatic fever (RF) which affects the most
disadvantaged LMIC citizens who are often impoverished, living in overcrowded circumstances, with marginal health literacy and inad‐equate health care access. 2 While the Accord does not give detailed arguments for the recommendations endorsed, on balanced reading, invested stakeholders may fret over a possible opportunity lost.
Capítulos de Livros Internacionais
Rheumatology - 9ª edição (2022)
Livro referência mundial em reumatologia editado pela Prof. Ellen Gravallese (chefe da reumatologia da Harvard Medical School e presidente da Sociedade Americana de Reumatologia).
Rheumatology Translational Autoimmunity: Advances in Rheumatic Disease - Volume 6 (2022)
Livro editado pelo Prof. Nima Rezaei (Professor Iraniano referência mundial em doenças imunológicas).
Participação em Pesquisas
Pesquisas científicas na USP-INCOR, Hospital Israelita Albert Einstein e parceria com as principais instituições cardiológicas nacionais, sobre cardio-oncologia (efeito do tratamento oncológico e do câncer no coração), doenças das válvulas do coração e doenças do músculo cardíaco.
Infarto em paciente oncológico
Hospital AC Camargo Câncer Center
Investigador principal no Hospital AC Camargo Câncer Center da pesquisa realizada na USP-INCOR, e em alguns centros de cardiologia no Brasil como Hospital Sírio Libanês, Hospital Beneficência Portuguesa, INCOR, Icesp entre outros. O objetivo principal é avaliar as características do infarto nos pacientes com câncer.
Takotsubo
Sociedade Brasileira de Cardiologia (SBC)
Pesquisa realizada nos principais centros cardiológicos do Brasil (USP, UNIFESP, HCOR, HOSPITAL PRÓ- CARDÍACO, COPA STAR, PUCPR e UFGO). Responsável pelo centro participante (Hospital AC Camargo Câncer Center) no Projeto de Pesquisa Registro Brasileiro de Takotsubo BR-R (Brazilian Registry). O objetivo da pesquisa é definir o perfil da Takotsubo no Brasil através das informações obtidas pela observação das características epidemiológicas, clínicas e prognósticas intra e extra hospitalares.
Doenças Valvares
USP - Incor e Hospital Albert Einstein
Pesquisador principal na investigação de doenças valvares causada pela febre reumática na comunidade do Capão Redondo e Jardim Ângela. Pesquisa realizada no Hospital Israelita Albert Einstein em parceria com a USP, foram avaliados 1.030 pacientes na comunidade. Essa pesquisa também é tese de doutorado do Dr. Carlos Branco na USP que deve ser finalizada em 2022-2023.






